5 cities in England beginning with a vowel are Aylesbury, Exeter, Ipswich, Exmouth, and Eastbourne.
5 cities in Scotland beginning with a vowel are Edinburgh, Aberdeen, Ayr, Airdrie, and Irvine.
5 cities in Northern Ireland beginning with a vowel are Enniskillen, Omagh, Aughnacloy, Antrim, and Armagh.
These are generally the largest cities or towns beginning with a vowel in the UK. The letter "A" is the most common vowel to start names of cities in the UK. Some other UK cities beginning with a vowel are Inverness, Ely, Abberley, Abingdon, Abington, Abram, Abridge, Accrington, Acton, Ealing, Easington, Ilkley, Ingrave, Innsworth, Oakdale, Oakham, Oakley, Underwood, and Upton.
Any city beginning with "Old" or "East" also begins with a vowel.